Six years ago, a catastrophic event ravaged Tokyo. Amaha Masune was found at ground zero, physically unscathed, but without memories and with a child in her arms. Returning to Tokyo for the first time since the disaster, the slightly clumsy but cheerful Masune just wants make a new life and to raise her daughter without interference from the Child Welfare Agency. But unsolved murders are being committed all over Tokyo and a near-miss reveals her identity as the bearer of the Witchblade, a mysterious weapon linked to the disaster 6 years before, that seems to have a mind of its own. Giving in to the Witchblade seems dangerous, but when the powerful Dohji Corporation agrees to guarantee her a life together with her daughter if she works for them, can Masune pass up the chance?