In the present, Japan is under assault by murderous creatures known as Aragami whose origin and purpose remain unknown. The fate of Japan and the world itself lies with one young woman named Momiji who bears the burden of the Kushinada -- the one who must be sacrificed to silence the Aragami forever. With the help of Mamoru Kusanagi (a human and Aragami hybrid), and an agency filled with firepower-toting bodyguards, Momiji must use her Aragami-sensing powers to help save mankind; but will she ultimately have to lose her own life to save the lives of so many others?